Meulemans, Ann,Lavrijsen, Karel,Cools, Marina,Keller, Erik,Mezine, Igor Alexnadrovich,Thielemans, Leen,Van Geffen, Maarten
申请号：
AU2010299916
公开号：
AU2010299916A1
申请日:
2010.09.23
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention relates to a novel class of [1,4]-benzodiazepine derivatives, processes for their preparation, intermediates usable in these processes, and pharmaceutical compositions containing the compounds. Other aspects of the invention are directed to the use of said [1,4]-benzodiazepine derivatives in therapy based on the capability of said compounds to interfere with the binding of the peptide hormone, vasopressin, to its receptors. In particular as vasopressin V2 receptor antagonists and therefore useful for treating involving increased vascular resistance, cardiac insufficiency, and water retention.
