The present invention relates to bispecific antibodies comprising at least two fab fragments, wherein the first Fab fragment comprises at least one antigen binding site specific for a first antigen； and the second Fab fragment comprises at least one antigen binding site specific for a second antigen, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged； and wherein the bispecific antibody is devoid of a Fc domain； methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
