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Pharmaceutical compositions and methods for fabrication of solid masses comprising immunoglobulins
专利权人:
发明人:
Mercedes Morales,Mir Imran,Radhika Korupolu,Mir Hashim
申请号:
US14714120
公开号:
US10098931B2
申请日:
2015.05.15
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Embodiments of the invention provide shaped masses comprising one or more drugs such as proteins or polypeptides and methods for forming such shaped masses. One embodiment provides a shaped mass comprising a drug such as a protein or polypeptide having a biological activity in the body of a mammal. The shaped mass is formed by compression of a precursor material comprising the drug wherein an amount of biologically active drug in the mass is a preserved above a minimum level. Drugs which may be incorporated into the shaped mass may include one or more glucose regulating proteins such as insulin, incretins and immunoglobulins such as TNF-inhibiting antibodies or interleukin neutralizing antibodies. Embodiments of the shaped mass may be incorporated into a tissue penetrating member which is inserted into the intestinal wall allowing for the oral delivery of proteins and peptides which would otherwise be degraded in the intestinal tract.
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