TS PHARMA;UNIVERSITE D'AVIGNON ET DES PAYS DU VAUCLUSE
发明人:
GREGORY DURAND,ANGE POLIDORI,BERNARD PUCCI,JEAN PIERRE SALLES
申请号：
FR0602355
公开号：
FR2898602B1
申请日:
2006.03.17
申请国别(地区):
FR
年份:
2012
代理人:
摘要：
alpha -C-Phenyl-N-tert butyl nitrone amphiphilic derivatives (I), are new. alpha -C-Phenyl-N-tert-butyl nitrone amphiphilic derivatives of formula (I), are new. X : hydrophilic group like mono-/polysaccharide e.g. amino derivative of mono-/polysaccharide, polyethylene oxide chain, peptide chain, polar ionic group like quaternary ammonium-, amine oxide-, carnitine-, phosphate- or choline group； m : 1-3； Y 1a spacer or a linker like ester, amide, urea, urethane, (thio)ether, amine, 1-6C hydrocarbon (optionally interrupted by a ester, amide, urea, urethane, ether amine or thio-ether)； Y 2ester-, amide-, urea-, urethane-, thio-ether-, amino acid- or serinol group； m1 : 1-2； and n : 0-2； X 1H or 4-14C alkyl (optionally substituted by F). An independent claim is included for the preparation of (I). [Image] ACTIVITY : Immunostimulant； Tranquilizer； Antiinflammatory； Vasotropic； Antiarteriosclerotic； Neuroprotective； Nootropic； Antiparkinsonian； Antiemetic； Cytostatic； Anticonvulsant. MECHANISM OF ACTION : None given.
