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Anhydrous crystalline form of Cabazitaxel, preparation procedure and pharmaceutical compositions thereof
专利权人:
Indena S.p.A.
发明人:
CABRI, Walter,CICERI, Daniele,DOMENIGHINI, Luca,GAMBINI, Andrea,PETERLONGO, Federico
申请号:
ES14789196
公开号:
ES2645478T3
申请日:
2014.10.09
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
An anhydrous crystalline form, referred to as form H, of Cabazitaxel of formula (I) ** Formula ** in which the anhydrous crystalline form has the following: - an X-RPD pattern obtained using the wavelengths of copper λ1 and λ2 1,54056 Å and 1,54439 Å, respectively, comprising distinctive reflections, expressed as values of grades 2-theta, at 5.8, 6.5, 8.1, 9.5, 10.9, 11.5 , 12.2, 13.0, 14.1, 14.8, 16.8, 17.2, 19.0, 19.4, 20.1, 21.9 and 24.0 ± 0.2;Una forma cristalina anhidra, referida como forma H, de Cabazitaxel de fórmula (I)**Fórmula** en la que la forma cristalina anhidra presenta lo siguiente: - un patrón X-RPD obtenido usando las longitudes de onda del cobre λ1 y λ2 de 1,54056 Å y 1,54439 Å, respectivamente, que comprende reflexiones distintivas, expresadas como valoreslde grados 2-theta, a 5,8, 6,5, 8,1, 9,5, 10,9, 11,5, 12,2, 13,0, 14,1, 14,8, 16,8, 17,2, 19,0, 19,4, 20,1, 21,9 y 24,0 ± 0,2;
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