METHOD FOR PREPARING A COMPLEX INFUSION PREPARATION AND USE THEREOF FOR CORRECTING HYPERPHOSPHATEMIA AND REDUCING VASCULAR IMPERMEABILITY IN PATIENTS WITH RENAL INSUFFICIENCY
FIELD: medicine.SUBSTANCE: group of inventions relates to the field of medicine, namely to a complex infusion preparation and a method for its preparation, which involves preparing the drug solution by dissolving the following preparation components in pre-treated and purified water for injections: sorbitol, sodium lactate, sodium chloride, potassium chloride, magnesium chloride or magnesium chloride hexahydrate, calcium gluconate, with the following ratio of components, wt. %: sorbitol - 5.0–7.0； sodium lactate in terms of dry substance - 1.6–2.2； sodium chloride - 0.5–0.7； potassium chloride - 0.025–0.035； magnesium chloride or magnesium chloride hexahydrate in terms of dry substance - 0.006–0.016； calcium gluconate - 0.015–0.025； water for injection is balance； at that, the method includes the following stages: a) water is injected into reactor for injection with temperature of 80–95 °C in amount of not more than 70 % of calculated amount； b) loading gluconate into the calcium reactor, stirring, cooling solution to 40–45 °C； c) charging sodium chloride into the reactor, stirring； d) charging a chloride or magnesium chloride hexahydrate into a magnesium reactor, stirring； e) loading potassium chloride into reactor, stirring； f) loading sorbitol into reactor, stirring； g) loading lactate into a sodium reactor, stirring； h) bringing solution volume with water for injections to 100 %, cooling solution to 20–25 °C, stirring and circulating a solution for at least 30 minutes； i) holding the solution while stirring for at least 1 hour for stabilization； j) filtering the solution in three steps； k) packing the preparation solution into bottles； l) sterilized bottles with solution of preparation and also refers to application of infusion complex preparation for correction of hyperphosphatemia and reduction of vascular impermeability in patients with renal insufficiency.EFFECT: group of inventions provides an improved method of preparing and adapting the composition of the
