ZIA VAHID,ERNEST A. CARRA,CHEN IRENE,KATIE ANN KEATON
申请号：
UY36176
公开号：
UY36176A
申请日:
2015.06.17
申请国别(地区):
UY
年份:
2016
代理人:
摘要：
The present invention relates to (2R, 5S, 13R) - 8-hydroxy-7, 9-diazo-n (2, 4, 6-trifluoroenzene) - 2, 3, 4, 5, 7, 9, 13-octahydro-2, 5-pyridine [1?] -2？ 4,5-pyridine [2,1-b] [1,3] oxazzapina-10-carboxamida, drug formulation and therapeutic use. The present invention also relates to novel crystal forms (2R, 5S, 13ar) - 7, 9-diazo-10 - (2, 4, 6-trifluoromethane) - 2, 3, 4, 5, 7, 9, 13-octahydro-2, 5-pyridan [1?] -2？ 4,5] pyridine [2,1-b] [1,3] oxazenpin-8-alento sodium form I.La presente invención se relaciona con formas cristalinas y co-cristales de (2R,5S, 13aR)-8-hidroxi-7,9- dioxo- N-(2,4,6 - trifluorobencil)-2,3,4,5,7,9,13,13a -octahidro -2,5-metanopirido[1?,2?,4,5]pirazino[2,1-b][1,3]oxazapina- 10-carboxamida, las formulaciones farmacéuticas, y los usos terapéuticos de las mismas. La presente invención también se relaciona con formas cristalinas novedosas de (2R, 5S, 13aR)-7,9- dioxo- 10-((2,4,6 - trifluorobencil)carbamoil)-2,3,4,5,7,9,13,13a -octahidro -2,5-metanopirido[1?,2?,4,5]pirazino[2,1- b][1,3]oxazepin - 8-olato de sodio Forma I.
