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DERIVE DE PYRAZOLOQUINOLINE
专利权人:
LTD.;EISAI R&D MANAGEMENT CO.
发明人:
NORIMINE, YOSHIHIKO,TAKEDA, KUNITOSHI,HAGIWARA, KOJI,SUZUKI, YUICHI,ISHIHARA, YUKI,SATO, NOBUAKI
申请号:
CA2861795
公开号:
CA2861795C
申请日:
2012.10.04
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
A compound or pharmacologically acceptable salt thereof represented by theformula(I) has PDE9 inhibitory action, so that the intracerebral cGMP concentrationis anticipated tobe elevated. The PDE9 inhibitory action and the increase in cGMP lead to theimprovementof learning and memory behaviors, and the compound (I) has a potential use ofa therapeuticagent for cognitive dysfunctions in Alzheimer's disease.(See Formula I)wherein IV is a hydrogen atom; R2 is an aromatic ring group, etc.; R3 is ahydrogen atom, etc;R4 is a hydrogen atom; R5 is an oxepanyl group, etc.; R6 is a hydrogen atom.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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