A universal fluid system connector creates an airtight seal between a variety of smoke evacuation system receptacles and various hoses. The universal connector includes a body and a seal having a plurality of radially extending flexible fins. A plurality of fins on the seal are disposed along the length of the body with the outer edges of the fins forming a frustoconical shape. The fins also include one or more flexion zones of various stiffness and one or more flexible fin extensions. The fins deform against the inner wall of a receptacle and form an airtight friction fit between the universal connector and the receptacle, regardless of the taper angle, size, threads, or other features of the receptacle.