KUHNE MICHELLE,ミシェル・キューネ,BRAMS PETER,ピーター・ブラムス,TANAMACHI DAWN M,ドーン・エム・タナマチ,KORMAN ALAN,アラン・コーマン,CARDARELLI JOSEPHINE M,ジョセフィン・エム・カルダレッリ
申请号：
JP2013153626
公开号：
JP2013227339A
申请日:
2013.07.24
申请国别(地区):
JP
年份:
2013
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide isolated monoclonal antibodies that specifically bind to CXCR4 with high affinity, particularly human monoclonal antibodies.SOLUTION: Isolated human monoclonal antibodies bind to human CXCR4 and have the ability to bind to native human CXCR4 expressed on a cell surface, the ability to inhibit SDF-1 binding to human CXCR4, the ability to inhibit SDF-1-induced calcium flux in cells expressing human CXCR4, the ability to inhibit SDF-1-induced migration of cells expressing human CXCR4, the ability to inhibit capillary tube formation by human umbilical vein endothelial cells, the ability to induce apoptosis in cells expressing human CXCR4, the ability to inhibit growth of CXCR4tumor cells.【課題】 ＣＸＣＲ４に高親和性で特異的に結合する単離モノクローナル抗体、特にヒトモノクローナル抗体を提供すること。【解決手段】 ＣＸＣＲ４に高親和性で特異的に結合する単離モノクローナル抗体、特にヒトモノクローナル抗体を見いだした。【選択図】なし
