Ayares David L.,Mendicino Michael,Wells Kevin,Dandro Amy S.
申请号：
US201514665517
公开号：
US10149461(B2)
申请日:
2015.03.23
申请国别(地区):
美国
年份:
2018
代理人:
King & Spalding
摘要：
Porcine animals, tissue and organs as well as cells and cell lines derived from such animals are provided that lack functional endogenous immunoglobulin loci and are deficient in immunoglobulin expression and B-cells. These animals are useful as model systems for research and for development of new pharmaceutical and biological agents. In addition, methods are provided to prepare such animals.
