BIAN, HAIYAN,CHEVALIER, KRISTEN M.,CONNOLLY, PETER J.,FLORES, CHRISTOPHER M.,LIN, SHU-CHEN,LIU, LI,MABUS, JOHN,MACIELAG, MARK J.,MCDONNELL, MARK E.,PITIS, PHILIP M.,ZHANG, SUI-PO,ZHANG, YUE-MEI,ZHU, B
申请号：
ES10715457
公开号：
ES2538326T3
申请日:
2010.04.22
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (I) Formula ** in which Y and Z are independently selected from a) or b), so that one of Y and Z is selected from group a) and the other is selected from group b)； Group a) is i) substituted C6-10 axyl, ii) C3-8 cycloalkyl, iii) trifluoromethyl； or iv) heteroaryl selected from the group consisting of thienyl, furanyl, thiazolyl, isothiazolyl, oxazolyl, pyrrolyl, pyridinyl, isoxazolyl, imidazolyl, furazan-3-yl, benzothienyl, thieno [3,2-b] thiophene-2-yl, pyrazolyl , triazolyl, tetrazolyl and [1,2,3] thiadiazolyl； wherein C6-10 aryl is replaced by； and the heteroaryl is optionally substituted by； from one to two substituents independently selected from the group consisting of fluorine, chlorine, bromine, C 1-4 alkyl, cyano and trifluoromethyl； Group b) is i) C6-10 aryl； ii) heteroaryl selected from the group consisting of thiazolyl, pyridinyl, indolyl, indazolyl, pyrrolyl, benzoxazolyl, benzothiazolyl, benzothienyl, benzofuranyl, imidazo [1, 2-a] pyridin-2-yl, furo [2,3-b] pyridinyl, furazan-3-yl, pyrrolo [2,3-b] pyridinyl, pyrrolo [3,2-b] pyridinyl, thieno [2,3-b] pyridinyl, quinolinyl, quinazolinyl, thienyl and benzimidazolyl； iii) benzofused heterocyclyl attached through a carbon atom, and when the heterocyclyl part contains a nitrogen atom, this nitrogen atom is optionally substituted by a substituent selected from the group consisting of C3-7 cycloalkylcarbonyl； C3-7 cycloalkylsulfonyl； phenyl； phenylcarbonyl； thienylcarbonyl； pyrrolyl carbonyl； phenylsulfonyl； phenyl (C1-4) alkyl； (C1-4 alkyl) aminocarbonyl； C1-6 alkylcarbonyl； C1-6 alkylcarbonyl-C1-4 alkyl； C1-6 alkylsulfonyl； pyrimidinyl； pyridinyl； and 4-4-4alkoxycarbonyl； wherein C3-7 cycloalkylcarbonyl, phenyl, phenylcarbonyl, phenyl (C1-4) alkyl and phenylsulfonyl are optionally substituted by trifluoromethyl or one to two fluorine substituents； and wherein the benzofused heterocyclyl is optionally substituted by an oxo carbon atom and optionally substituted independently by one to t
