MAHIDOL UNIVERSITY;THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION
发明人:
KINNEY, Richard M.,KINNEY, Claire Y.H.,BUTRAPET, Siritorn,GUBLER, Duane L.,BHAMARAPRAVATI, Natth
申请号：
AU2015213355
公开号：
AU2015213355B2
申请日:
2015.08.13
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
#$%^&*AU2015213355B220171005.pdf#####ABSTRACT Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural protein genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
