The present disclosure relates to TGF-beta antibodies and binding fragments thereof, DNA encoding the same, host cells comprising said DNA and methods of expressing the antibody or binding fragment in a host cell. The disclosure also extends to pharmaceutical compositions comprising the antibody or a binding fragment thereof and use of the antibody, binding fragment and compositions comprising the same in treatment of various diseases including fibrosis.本發明係關於TGF-β抗體及其結合片段、編碼該等之DNA、包含該DNA的宿主細胞及使該抗體或結合片段在宿主細胞中表現之方法。本發明亦擴展至包含該抗體或其結合片段之醫藥組合物以及該抗體、結合片段及包含該等的組合物在治療包括纖維化在內的各種疾病中之用途。