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TGF- 1 SPECIFIC ANTIBODIES AND METHODS AND USES THEREOF
专利权人:
LUDWIG INSTITUTE FOR CANCER RESEARCH LIMITED
发明人:
VAN SNICK, JACQUES,UYTTENHOVE, CATHERINE,BOON, THIERRY
申请号:
EP13758033
公开号:
EP2822592A4
申请日:
2013.03.06
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
Specific binding members, particularly antibodies and fragments thereof, which bind to transforming growth factor beta 1 (TGF-β1) are provided, particularly recognizing human and mouse TGF-β1 and not recognizing or binding TGF-β2 or TGF-β3. Particular antibodies are provided which specifically recognize and neutralize TGF-β1. These antibodies are useful in the diagnosis and treatment of conditions associated with activated or elevated TGF-β1, including cancer, and for modulating immune cells and immune response, including immune response to cancer or cancer antigens. The anti-TGF-β1 antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies hereof, including antibody 13A1, whose sequences are provided herein.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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