CAPONIGRO, GIORDANO,MEYER, MATTHEW JOHN,COOKE, VESSELINA,STUART, DARRIN
申请号：
CA3037456
公开号：
CA3037456A1
申请日:
2017.09.18
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relates to a combination treatment which comprises (a) at least one ERK inhibitor preferably Compound B as described herein, and (b) a c-RAF inhibitor or a pharmaceutically acceptable salt thereof, preferably Compound A, which may be combined into a single pharmaceutical composition or prepared for separate or sequential administration. It includes a c-RAF inhibitor and an ERK inhibitor prepared for simultaneous, separate or sequential administration for the treatment of a proliferative disease, particularly an advanced solid tumor that harbors a Mitogen-activated protein kinase (MAPK) alteration, and includes methods of using these compounds in combination as well as a commercial package comprising such combination.
