The present invention generally relates to fusion proteins of antibodies and interleukin-10 (IL-10). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the fusion proteins of the invention, and to methods of using them in the treatment of disease.本發明概言之係關於抗體與介白素-10(IL-10)之融合蛋白。另外,本發明係關於編碼此等融合蛋白之聚核苷酸以及包含此等聚核苷酸之載體及宿主細胞。本發明進一步係關於產生本發明融合蛋白之方法及使用其治療疾病之方法。