This refers to a long-term pharmaceutical component, which contains an active physiological polypeptide that binds a part of immunoglobulin, It contains a monomer copolymer, which is composed of a physiologically active polypeptide molecule and an immunoglobulin single segment, Or, it includes a complex composed of two or more same physical active polypeptide molecules and a single immunoglobulin fragment, provided that the molecular ratio from unit to multiple transposition is at least 19；Fc fragment of immunoglobulin, a monomer mixture of physically active polypeptide, includes a monomer of physiologically active polypeptide, which is connected to Fc fragment of an immunoglobulin through a non cucumber, The physical active polypeptide is combined with the immunoglobulin part, by combining the non cucumber with the immunoglobulin part of monosomic form,Compared with a binary complex composed of two physically active polypeptide molecules, by connecting the non cucumber to the FC part of an immunoglobulin, through the mediation of the receiver or the mediation purification of the receiver, the reduced internal displacement is displayed, Or a complex, including one tenth of a physiologically active polypeptide combined with an Fc fragment of an immunoglobulin； and a method of preparing a drug component for long-term action.La presente se refiere a: una composición farmacéutica de acción prolongada que contiene un conjugado que comprende un polipéptido fisiológicamente activo unido a un fragmento Fc de inmunoglobulina, en la que la contiene un conjugado monomérico que comprende una molécula del polipéptido fisiológicamente activo unido a un fragmento Fc de inmunoglobulina único, y opcionalmente contiene un conjugado multimérico que comprende dos o más moléculas del mismo polipéptido fisiológicamente activo unido a un fragmento Fc de inmunoglobulina único, con la condición de que la relación molar del conjugado monomérico al conjugado multimérico en la composición sea
