ECKELMAN, Brendan P.,TIMMER, John C.,NGUY, Peter L.,GUENTHER, Grant B.,DEVERAUX, Quinn
申请号：
MX2013015323
公开号：
MX356517B
申请日:
2012.06.28
申请国别(地区):
MX
年份:
2018
代理人:
摘要：
This invention relates to molecules, particularly polypeptides, more particularly fusion proteins that include a serpin polypeptide or an amino acid sequence that is derived from a serpin and second polypeptide comprising of at least one the following: an Fc polypeptide or an amino acid sequence that is derived from an Fc polypeptide； a cytokine targeting polypeptide or a sequence derived from a cytokine targeting polypeptide； a WAP domain containing polypeptide or a sequence derived from a WAP containing polypeptide； and an albumin polypeptide or an amino acid sequence that is derived from a serum albumin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules.La presente invención se refiere a una proteína de fusión aislada, caracterizada porque comprende por lo menos un polipéptido de serpina de humano que comprende un polipéptido de alfa-1 antitripsina (AAT) de humano que comprende una secuencia de aminoácidos seleccionada del grupo que consiste de SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID: 32 y SEQ ID NO:33, en donde el polipéptido de AAT está enlazado operablemente a un polipéptido de Fc de inmunoglobulina que comprende la secuencia de aminoácidos de SEQ ID NO: 6.
