The present invention provides methods of preventing insulin resistance including administering to a subject in need thereof an effective amount of a designated IR-B Proprietary Blend. IR-B Proprietary Blend can be used to antagonize/scavenge/reduce/diminish/blunt/inhibit/suppress reactive oxygen radicals (ROS). IR-B Proprietary Blend can be used to support/help/promote/enhance gene transcription. IR-B Proprietary Blend can be used to promote/improve/stimulate/enhance/amplify microcirculation. Insulin resistance or metabolic disorders that can be prevented by using the present invention include diabetes, hyperglycemia, insulin resistance, hyperinsulinemia, obesity, atherosclerosis, heart attack, stroke, hyperlipidemia and hyperlipoproteinemia, and accelerated aging.
