Combination of T-cell redirecting multifunctional antibodies with immune checkpoint modulators and uses thereof

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专利权人:

Horst Lindhofer

发明人:

Lindhofer, Horst,Ruf, Peter

申请号：

AU2017369540

公开号：

AU2017369540A1

申请日:

2017.11.29

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

The present invention provides a combination of (i) an immune checkpoint modulator and (ii) a T-cell redirecting multifunctional antibody, or an antigen binding fragment thereof, for use in therapeutic treatment of a cancer disease. The T-cell redirecting multifunctional antibody comprises (a) a specificity against a T cell surface antigen； (b) a specificity against a cancer- and/or tumor-associated antigen； and (c) a binding site for human FcRI, FcyRlla and/or FcyRlll, wherein the antibody, or the antigen binding fragment thereof, binds with a higher affinity to human FcyRI, FcyRlla and/or FcyRlll than to human FcyRllb.

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