COMBINAISON D'ANTICORPS MULTIFONCTIONNELS REDIRIGEANT LES LYMPHOCYTES T AVEC DES MODULATEURS DE POINT DE CONTROLE IMMUNITAIRES ET UTILISATIONS ASSOCIEES

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专利权人:

LINDHOFER; HORST

发明人:

LINDHOFER, HORST,RUF, PETER

申请号：

CA3043656

公开号：

CA3043656A1

申请日:

2017.11.29

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present invention provides a combination of (i) an immune checkpoint modulator and (ii) a T-cell redirecting multifunctional antibody, or an antigen binding fragment thereof, for use in therapeutic treatment of a cancer disease. The T-cell redirecting multifunctional antibody comprises (a) a specificity against a T cell surface antigen； (b) a specificity against a cancer- and/or tumor-associated antigen； and (c) a binding site for human FcRI, FcyRlla and/or FcyRlll, wherein the antibody, or the antigen binding fragment thereof, binds with a higher affinity to human FcyRI, FcyRlla and/or FcyRlll than to human FcyRllb.

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