It is disclosed a method for treating hepatitis B virus infection or hepatitis B virus / hepatits delta virus co-infection, the method comprising administering to a subject in need of such treatment a first pharmaceutically acceptable agent that comprises at least one phosphorothioated nucleic acid polymer and a second pharmaceutically acceptable agent that comprises at least one nucleoside / nucleotide analog HBV polymerase inhibitor.本文揭示治療B型肝炎病毒感染或B型肝炎病毒/肝炎δ病毒共感染之方法，該方法包含向需要該治療之個體投與包含至少一種硫代磷酸酯化核酸聚合物之第一醫藥上可接受之藥劑及包含至少一種核苷/核苷酸類似物HBV聚合酶抑制劑之第二醫藥上可接受之藥劑。
