B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD.;YEDA RESEARCH AND DEVELOPMENT CO. LTD.
发明人:
Irun R. Cohen,Bracha Rager-Zisman,Angel Porgador,Johannes Herkel
申请号：
US14146549
公开号：
US20140120126A1
申请日:
2014.01.02
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides improved vaccines comprising an isolated viral antigenic peptide and a synthetic peptide derived from a T cell epitope of HSP60. The invention includes mixtures where the peptide serves as an adjuvant as well as conjugates where the peptide is covalently linked to the viral antigen. The known synthetic peptide carrier, p458, provides significantly improved immunogenicity for synthetic viral epitopes and analogs. Ec27 is a novel peptide derived from HSP60 which increases the immunogenicity substantially of the viral antigen both as a mixture or a covalent conjugate. Some of the isolated viral epitopes are novel and are claimed for diagnostic as well as therapeutic or prophylactic uses.
