George M. Shaw,James E. Robinson,Frederic Bibollet-Ruche,Julie M. Decker,Beatrice H. Hahn,Peter D. Kwong
申请号：
US11578761
公开号：
US08637234B2
申请日:
2005.04.08
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Methods and compositions are provided for the use of an envelope polypeptide or a functional variant thereof from a lentivirus that is not HIV-1 as a molecular scaffold for HIV-1 epitopes. The HIV-1 epitopes can be recognized by HIV-1 binding antibodies, HIV-1 neutralizing antibodies and/or CD4-induced antibodies. Thus, methods are provided for detecting HIV-1 binding antibodies in a subject infected with HTV-1. Further provided are methods to determine an epitope for an HIV-1 binding antibody methods to assay for an HIV-1 binding antibody methods to identify a soluble CD4 mimic methods to neutralize an non-HIV-1 virus diagnostic assays to monitor HIV disease in a subject or to monitor the subjects response to immunization by a HIV vaccine and methods to alter the neutralization potential of an HIV-1 derived CD4-induced antibody. Chimeric polypeptides, chimeric polynucleotides, kits, cells and viruses are also provided.
