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LONG-LIVED GADOLINIUM BASED TUMOR TARGETED IMAGING AND THERAPY AGENTS
专利权人:
WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人:
WEICHERT, JAMEY,PINCHUK, ANATOLY,TOME, WOLFGANG
申请号:
CA3004458
公开号:
CA3004458A1
申请日:
2016.11.04
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
Alkylphosphocholine analogs incorporating a chelating moiety that is chelated to gadolinium are disclosed herein. The alkylphophocholine analogs are compounds having the formula: (I) or a salt therof. R1 includes a chelating agent that is chelated to a gadolinium atom a is 0 or 1 n is an integer from 12 to 30 m is 0 or 1 Y is -H, -OH, -COOH, -COOX, -OCOX, or -OX, wherein X is an alkyl or an arylalkyl R2 is -N+H3, -N+H2Z, -N+HZ2, or -N+Z3, wherein each Z is independently an alkyl or an aroalkyl and b is 1 or 2. The compounds can be used to detect solid tumors or to treat solid tumors. In detection/imaging applications, the gadolinium emits signals that are detectable using magnetic resonance imaging. In therapeutic treatment, the gadolinium emits tumor-targeting charged particles when exposed to epithermal neutrons.
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