According to the present invention, a substance derived from a living body that can promote cell proliferation and differentiation, a method for evaluating cell proliferation and differentiation targeting the substance derived from the living body, and a molecule that binds to the substance derived from the living body as an active ingredient A composition for detecting the proliferation and differentiation of the cells and a composition for promoting the proliferation and differentiation of the cells containing the living body-derived substance as an active ingredient are provided. In the present invention, in the process of cell proliferation and differentiation, a part of the sulfated polysaccharide secreted from the cell binds to the growth factor, and from the cell of the sulfated polysaccharide exhibiting such binding property. The amount of secreted gas is strongly correlated with the growth and differentiation of cells, and by utilizing the sulfated polysaccharides, the growth and differentiation of cells can be evaluated and the growth and differentiation of cells can be promoted. I found it possible.本発明により、細胞の増殖および分化を促進しうる生体由来の物質、並びに、当該生体由来の物質を標的とした細胞の増殖および分化の評価方法、当該生体由来の物質に結合する分子を有効成分とする細胞の増殖および分化を検出するための組成物、および当該生体由来の物質を有効成分とする細胞の増殖および分化を促進するための組成物が提供される。本発明では、細胞の増殖および分化の過程において、細胞から分泌される硫酸化多糖類の一部が、成長因子に結合すること、および、このような結合性を示す硫酸化多糖類の細胞からの分泌量が、細胞の増殖および分化の進行と強い相関を示すこと、当該硫酸化多糖類を利用することにより、細胞の増殖および分化の評価や、細胞の増殖および分化の促進を行うことが可能であることを見出した。
