The present invention relates to a particle formed from a mixed liquid of docosahexaenoic acid and monoolein dispersion, a transdermal transmitter using the same, and a manufacturing method of the same. The particle according to the present invention can be usefully used as a drug delivery system or a transdermal transmitter (or oral transmitter) of protein and nucleic acid.COPYRIGHT KIPO 2018본 발명은 도코사헥사엔산(Docosahexaenoic Acid) 및 모노올레인(Mono Olein) 분산액의 혼합액으로부터 형성되는 결정체(Particle), 이를 이용한 경피전달체 및 그 제조방법에 관한 것이다.