SZLAVIK, Zoltan,SZABO, Zoltan,CSEKEI, Marton,PACZAL, Attila,KOTSCHY, Andras,BRUNO, Alain,GENESTE, Olivier,CHEN, I-Jen,DAVIDSON, James Edward Paul,MURRAY, James Brooke,ONDI, Levente,RADICS, Gabor,SIPOS
申请号:
PE2017002702
公开号:
PE20190111A1
申请日:
2016.06.22
申请国别(地区):
PE
年份:
2019
代理人:
摘要:
For compounds of carbamate (I) extracted from the formula,A represents group A1, of which group 1 is connected with a-nh-2 and 2 with aromatic ring; e represents cyclopropyl, isocyclopropyl, etc.; X is n or c-r4; y is n or c-r3; R1 is halogenation, alkyl (C1-C6) linear or branched; R2, R3, R4 and R5 are independent hydrogen and halogenation, 1. Alkyl (C1-C6) is linear or branched; R6 is hydrogen, halogen, halogenation, halogenation (C2-C6) linear or branched, other organisms; R7 is hydrogen, hydrocarbon (C1-C8) linear or branched, among others; R8 is linear or branched, halogenated (C2-C6) is linear or branched, and so on; R12 is hydrogen geno, hydroxi or hydroxuil-c6;N is 0, 1 or 2. 1. A selected compound is - [5 - {3-chloro-2-methyl-4 - [2 - (4-methylpiperazin-1-il) etoxi] phenyl} - 6 - (4-fluorofenil) - tieno [2, 3-d] pirimidin-4-il] - 2 - [(1-methyl-1h-pirazol-5-il) methoxi] - d-fenillanina. It also refers to a process for your medication preparation and composition to understand them. These compounds are biased and therefore useful in the treatment of cancer and immune and autoimmune diseases.Referido a compuestos derivados de aminoacido de formula (I), en la que A representa el grupo A1, en la que 1 esta unido a -NH- y 2 esta unido al anillo aromatico; E representa un cicloalquilo, heterocicloalquilo, entre otros; X es N o C-R4; Y es N o C-R3; R1 es halogeno, alquilo(C1-C6) lineal o ramificado, entre otros; R2, R3, R4 y R5 son, independientemente, hidrogeno, halogeno, alquilo(C1-C6) lineal o ramificado; R6 es hidrogeno, halogeno, alquenilo (C2-C6) lineal o ramificado, ente otros; R7 es hidrogeno, alquilo(C1-C8) lineal o ramificado, entre otros; R8 es alquilo (C1-C6) lineal o ramificado, alquenilo(C2-C6) lineal o ramificado, entre otros; R12 es hidrogeno, hidroxi o hidroxialquilo(C1-C6); n es 0, 1 o 2. Un compuesto seleccionado es -N-[5-{3-cloro-2-metil-4-[2-(4-metilpiperazin-1-il)etoxi]fenil}-6-(4-fluorofenil)-tieno[2,3-d]pirimidin-4-il]-2-[(1-metil-1H-pirazol