NOUVELLE ENZYME HAUTEMENT FONCTIONNELLE AYANT UNE SPECIFICITE DE SUBSTRAT S-HEXOSAMINIDASE HUMAINE MODIFIEE, ET PRESENTANT UNE RESISTANCE A LA PROTEASE
LSIP, LLC;MEIJI PHARMACEUTICAL UNIVERSITY;TOKUSHIMA UNIVERSITY
发明人:
ITO, KOJI,SAKURABA, HITOSHI,TSUJI, DAISUKE
申请号：
CA2888628
公开号：
CA2888628A1
申请日:
2013.10.17
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Provided is an improved ß-subunit of human ß-hexosaminidase, having activity derived from a a-subunit of wild-type human ß-hexosaminidase, and having resistance to protease. A protein comprising, in the amino acid sequence for a ß-subunit of wild-type human ß-hexosaminidase, an amino acid sequence in which the 312th-318th amino acids have been substituted, in order, for glycine, serine, glutamic acid, proline, serine, glycine and threonine respectively.
