596154 Disclosed herein is a compound of formula (I-a) or a pharmacologically acceptable salt thereof wherein the variables are defined in the specification, and the use of said compound in the treatment or prevention of a disease associated with bone metabolism such as osteoporosis. Embodiments of the compound include the following: 4-[4-(propan-2-yloxy)phenyl]isoquinoline-6-carboxamide, and 8-{ 4-[2-(tetrahydro-2H-pyran-4-yloxy)ethoxy]phenyl} -1,6-naphthyridine-2-carboxamide