The present invention provides a method of treating cancer involvingadministering an insulin-like growth factor-1 receptor (IGF-1 receptor)agonist and an anti-cancer chemotherapeutic agent. Also provided are compoundsfor treating cancer comprising an IGF-1-receptor ligand coupled to an anti-cancer chemotherapeutic agent. Also provided are compounds for treating cancercomprising an insulin-receptor ligand coupled to an anti-cancerchemotherapeutic agent.