Methods, apparatus, and other embodiments associated with classifying a region of tissue using textural analysis are described. One example apparatus includes an image acquisition logic that acquires an image of a region of tissue demonstrating GGO nodule pathology, a delineation logic that distinguishes GGO nodule tissue within the image from the background of the image, a texture logic that extracts a set of texture features from the image, a phenotype signature logic that computes a phenotypic signature from the image, a shape logic that extracts a set of shape features from the image, and a classification logic that classifies the GGO nodule tissue based, at least in part, on the set of texture features, the phenotypic signature, or the set of shape features. A prognosis for a patient may be provided based on the classification of the image.
