SKINNER MURRAY,HEWINGS SIMON,PACKER DUNCAN,POLAND RICHARD
申请号：
CO13255473
公开号：
CO6910162A2
申请日:
2013.10.28
申请国别(地区):
CO
年份:
2014
代理人:
摘要：
A method of preparing a composition comprising one or more antigens adsorbed to an amino acid wherein said method comprises: (i) mixing a solution of one or more antigens with a solution of the amino acid in an aqueous acid whilst neutralizing the mixture of solutions, thereby forming an adsorbate comprising the one or more antigens and the amino acid； (ii) separating the adsorbate into a desired buffer by cross-flow filtration thereby forming said composition； and (iii) recovering said composition； wherein steps (i) to (iii) are performed in a sterile environment and within a closed system.
