FIELD: medicine； pharmaceuticals.SUBSTANCE: invention relates to a 4-alkynyl imidazole derivative represented by general formula (1) or a pharmaceutically acceptable salt thereof. In formula (1), ring A is C4-C8cycloalkyl, phenyl optionally substituted with C1-C4alkyl group or 6-membered heteroaryl containing one nitrogen atom as a ring atom； ring B is phenyl or 6-membered heteroaryl containing one nitrogen atom as a ring atom； m is an integer having any value from 0 to 1； n is an integer having any value from 1 to 3； R1 is a C1-C4 alkyl group, a halogen atom, C3-C8cycloalkyl or C1-C4 haloalkyl group； R2 and R3, each independently represent a hydrogen atom, a halogen atom or C1-C4 alkyl group, or taken together with the carbon atom with which R2 and R3 are adjacent, can form C3-C6 carbon ring； R4 and R5, each independently represent a hydrogen atom or C1-C4 alkyl group, or taken together with the carbon atom with which R4 and R5 are adjacent, can form C3-C6 carbon ring, and R6 and R7, each independently represent a hydrogen atom, C1-C4 alkyl group, C1-C4 alkoxy group, a halogen atom, C1-C4 haloalkyl group or C1-C4 haloalkoxy group； X is -OR8, or a halogen atom； R8 is a hydrogen atom or C1-C4 alkyl group； Y is a single bond or an oxygen atom； and E is -CO2H, -CO2P, which is an alkyl ester or bioisostere of a carboxyl group selected from tetrazolyl or oxadiazolonyl. Invention also relates to a pharmaceutical agent having an antagonistic action against EP4 and an antagonist of an EP4 receptor. (1).EFFECT: technical result: novel compounds of general formula (1) having an antagonistic effect on EP4, which are useful as pharmaceutical agents for the treatment of diseases associated with the EP4 receptor.20 cl, 23 tbl, 24 exИзобретение относится к 4-алкинилимидазольному производному, представленному общей формулой (1), или к его фармацевтически приемлемой соли. В формуле (1) кольцо A представляет собой С4-С8циклоалкил, фенил, необязательно замещенный С
