Stephen Jacob GOLDFLESS,Brian BELMONT,Cameron BRANDT,Alexandra CROFT,David Jeffrey HUSS
申请号：
US16374729
公开号：
US20190321401A1
申请日:
2019.04.03
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided herein are binding molecules, such as those that recognize or bind a peptide epitope of a cancer antigen, such as expressed on a cancer cell, including cells infected with human papilloma virus (HPV) or that contain HPV DNA sequences and/or those that recognize or bind a peptide epitope of HPV 16 E6 or E7, in the context of a major histocompatibility complex (MHC) molecule. Among the provided binding molecules are T cell receptors (TCRs) or antibodies, including antigen-binding fragments thereof, that bind or recognize such peptide epitopes. The present disclosure further relates to engineered cells comprising such binding molecules, e.g., TCRs or antibodies (and chimeric antigen receptors containing the antibodies), and uses thereof in adoptive cell therapy.
