Compounds quinoline derivatives as inhibitors of pde10a Enzyme； Pharmaceutical composition that comprises； and its use for the treatment of neurodegenerative and Psychiatric disorder.
PÜSCHL, ASK,KEHLER, JAN,NIELSEN, JACOB,KILBURN, JOHN PAUL,LANGGÄRD, MORTEN
申请号：
CL2014001643
公开号：
CL2014001643A1
申请日:
2014.06.19
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The present invention provides quinoline derivatives of formula I that are PDE10A enzyme inhibitors, and as such are useful to treat neurodegenerative and psychiatric disorders. Especially, the invention provides compounds that are highly selective for PDE10 over other PDE subtypes. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating disorders using the compounds of the invention.COMPUESTOS DERIVADOS DE 5,8-DIMETIL–[1,2,4]TRIAZOLO[1,5-A]PIRAZIN-2-IL)ETIL)-QUINOLINA, COMO INHIBIDORES DE LA ENZIMA PDE10A； COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENDE； Y SU USO PARA EL TRATAMIENTO DE UN TRASTORNO PSIQUIÁTRICO O NEURODEGENERATIVO.
