Heteroarilos substituted compounds and their salts as inhibitors of PI3K； Pharmaceutical composition that comprises, useful for treating proliferative disorders, inflammatory and cardiovascular disorders.

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专利权人:

INC.;MILLENNIUM PHARMACEUTICALS

发明人:

FREEZE, BRIAN, S.,HIROSE, MASAAKI,HU, YONGBO,HU, ZHIGEN,LEE, HONG MYUNG,SELLS, TODD, B.,SHI, ZHAN,VYSKOCIL, STEPAN,XU, TIANLIN

申请号：

CL2013000417

公开号：

CL2013000417A1

申请日:

2013.02.11

申请国别(地区):

CL

年份:

2014

代理人:

摘要：

This invention provides compounds of formula IA-a or IB-a and subsets thereof: wherein Z, HY, R1, R2, G1, W, n, and A and subsets thereof are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.COMPUESTOS DERIVADOS DE HETEROARILOS SUSTITUIDOS, SUS SALES； SUS COMPOSICIONES FARMACÉUTICAS； Y SU USO COMO INHIBIDORES DE P13K PARA TRATAR TRASTORNOS PROLIFERATIVOS, INFLAMATORIOS O CARDIOVASCULARES TALES COMO CÁNCER, MELANOMA, ALERGIAS, ANAFILAXIAS, INFLAMACIÓN AGUDA, ARTRITIS REUMATOIDE, TRASTORNOS AUTOINMUNES, TROMBOSIS, HIPERTENSIÓN.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/