THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人:
WEAVER, SCOTT C.,FROLOV, ILYA V.,FROLOVA, ELENA
申请号：
CA2713165
公开号：
CA2713165C
申请日:
2009.01.23
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention discloses an attenuated recombinant alphavirus that isincapable of replicating in mosquitocells and of transmission by mosquito vectors. These attenuated alphavirus mayinclude but is not limited to Western Equine En-cephalitisvirus, Eastern equine encephalitis virus, Venezuelan equine encephalitis virusor Chikungunya virus. The present inven-tionalso discloses the method of generating such alphaviruses and their use asimmunogenic compositions.
