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Attenuated Recombinant Alphaviruses Incapable of Replicating in Mosquitoes and Uses Thereof
专利权人:
发明人:
Scott C. Weaver,Ilya V. Frolov,Elena Frolova
申请号:
US15443364
公开号:
US20170240919A1
申请日:
2017.02.27
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention discloses an attenuated recombinant alphavirus that is incapable of replicating in mosquito cells and of transmission by mosquito vectors. These attenuated alphavirus may include but is not limited to Western Equine Encephalitis virus, Eastern equine encephalitis virus, Venezuelan equine encephalitis virus or Chikungunya virus. The present invention also discloses the method of generating such alphaviruses and their use as immunogenic compositions.
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中国工程科技知识中心
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