The Board of Regents of the University of Texas System
发明人:
Scott C. Weaver,Ilya V. Frolov,Elena Frolova
申请号：
US13855960
公开号：
US09580690B2
申请日:
2013.04.03
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention discloses an attenuated recombinant alphavirus that is incapable of replicating in mosquito cells and of transmission by mosquito vectors. These attenuated alphavirus may include but is not limited to Western Equine Encephalitis virus, Eastern equine encephalitis virus, Venezuelan equine encephalitis virus or Chikungunya virus. The present invention also discloses the method of generating such alphaviruses and their use as immunogenic compositions.
