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Substitutes for 5,6,7,8-tetrahydro [1,2,4] trimeric [4,3-a] pyridine-3 (2H) - nitrogen, 2,5,6,7-tetrahydro-3h-pyro [2,1-c] [1,2,4] triazole-3 -
专利权人:
BAYER AKTIENGESELLSCHAFT;BAYER PHARMA AKTIENGESELLSCHAFT
发明人:
BIBER, Nicole,BROCKSCHNIEDER, Damian,GERICKE, Kersten Matthias,KOLLING, Florian,LUSTIG, Klemens,MEDING, Jorg,MEIER, Heinrich,NEUBAUER, Thomas,SCHAFER, Martina,TIMMERMANN, Andreas,ZUBOV, Dmitry,TERJUNG
申请号:
PE2018002337
公开号:
PE20190325A1
申请日:
2017.05.08
申请国别(地区):
PE
年份:
2019
代理人:
摘要:
Refers to formula compound (I),where A is (C1-C4) alkylene or CD2, where (C1-C4) alkylene can be substituted with hydroxyl and (C1-C4) alkoxy and even pentasubstituted with fluorine; or is a group of formula (a),N equals 0 or 1; P equals 0 or 1; Q equals 1 or 2; 35; 1 tag is connected with nitroglycerin of 5-oxo-4, 5-dihydro-1h-1, 2, 4, triazol-1-ilo; tag is connected with R1; X es-cr6r7,-CR6R7-CR8R9--among others, where # 2 marks the bond with the carbon atom of the R4R5 group, where it marks the bond with the carbon atom of the 5-oxo-4,4-dihydro-1H-1,2,4-triazol-1 ring -ilo; R1 is cycloalkyl (3-C7) phenyl or heteroaryl with 5 to 10 members, among others; R2 is a group of formula (b),where # 3 marks the bond with the carbonyl carbon atom, r is 0 or 1, Z is O, NR18, S, SO, among others; R12 is hydrogen, cyano, (C1-C4) alkyl,R13 is, inter Alia, hydrogen, fluorine or bitumen (C1-C4);R3 is hydrogen or tar (C1-C4);R4 is h, tar (C1-C4),alcoxi (C1-C4)Fluorination, including; R5 is h or tar (C1-C4),There, any substance (C1-C4) can be replaced by pentachlorofluorobenzene. These compounds include 5,6,7,8-tetrahydro [1,2,4] pyridine-3 [4,3-a] pyridine-3 (2H) - onas and 2,5,6,7-tetrahydro-3h-pyrrole compounds [2,1-c] [1,2,4] triazol-3-substitutes; they also include their preparation, use alone or in combination in the production of drugs for the treatment and / or prevention of diseases, in particular, Treatment and / or prevention of lung inflammation.Referido a compuestos de formula (I), en donde A es alquileno (C1-C4) o CD2, donde alquileno (C1-C4) puede estar sustituido con hidroxilo y alcoxi(C1-C4) y hasta pentasustituido con fluor; o es un grupo de formula (a), en donde n es 0 o 1; p es 0 o 1; q es 1 o 2; #1 marca el enlace con el atomo de nitrogeno del anillo 5-oxo-4,5- dihidro-1H-1,2,4,triazol-1-ilo; marca el enlace con R1; X es -CR6R7-, #2-CR6R7-CR8R9- , entre otros, donde #2 marca el enlace con el atomo de carbono del grupo R4R5, donde marca el enlace con el atomo de
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