Method for producing sulfated derivative of 3,5-diiodo-O- [3-iodophenyl] -L-tyrosine

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专利权人:

ブラッコ・イメージング・ソシエタ・ペル・アチオニ

发明人:

ピエル・ルチオ・アネッリ,マリア・アルジェーゼ,ヴァレリア・ボイ,リヴィオ・カヴァリエーリ,ラウラ・ガリンベルティ,ソニア・ガッツェット,ルチアーノ・ラットゥアーダ,フェデリコ・マイザノ,ジョヴァンニ・リヴォルタ,フルヴィア・ヴェッラ

申请号：

JP2017123294

公开号：

JP6389927B2

申请日:

2017.06.23

申请国别(地区):

JP

年份:

2018

代理人:

摘要：

The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.

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