Anti-FGF19 antibodies and methods using same

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专利权人:

INC.;GENENTECH

发明人:

DESNOYERS, LUC,FRENCH, DOROTHY

申请号：

NZ56995707

公开号：

NZ569957A

申请日:

2007.02.09

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed are anti-FGF19 antibodies, and compositions comprising and methods of using these antibodies, methods using anti-FGF19 antibodies, and methods comprising detection of FGF19 and/or FGFR4. The anti-FGF19 antibody comprising: (a) a light chain comprising (i) HVR (hypervariable region)-L1 comprising sequence KASQDINSFLS (SEQ ID NO: 1)； (ii) HVR-L2 comprising sequence RANRLVD (amino acids 50-56 of SEQ ID NO:4)； and (iii) HVR-L3 comprising sequence LQYDEFPLT (SEQ ID NO:3)； and (b) a heavy chain comprising (i) HVR-H1 comprising sequence TYGVH (SEQ ID NO:5)； (ii) HVR-H2 comprising sequence VIWPGGGTDYNAAFIS (SEQ ID NO:6)； and (iii) HVR-H3 comprising sequence KEYANLYAMDY (SEQ ID NO:7).

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中国工程科技知识中心

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