Louis Picker,Scott Hansen,Klaus Frueh,Daniel Malouli,Jay Nelson,Jonah Sacha,Meaghan Hancock
申请号：
US15786847
公开号：
US20180133321A1
申请日:
2017.10.18
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed are CMV vectors that lack active UL128, UL130, UL146 and UL147 proteins that may also comprise one or more microRNA regulatory elements (MRE) that restrict expression of the CMV. Immunization with the disclosed CMV vectors allow selection of different CD8+ T cell responses—CD8+ T cells restricted by MHC-Ia, MHC-II, or by MHC-E.
