Cytomegalovirus vectors eliciting t cells restricted by major histocompatibility complex e molecules

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专利权人:

OREGON HEALTH AND SCIENCE UNIVERSITY

发明人:

申请号：

IL26601119

公开号：

IL266011D0

申请日:

2019.04.14

申请国别(地区):

IL

年份:

2019

代理人:

摘要：

Disclosed are CMV vectors that lack active UL128, UL130, UL146 and UL147 proteins that may also comprise one or more microRNA regulatory elements (MRE) that restrict expression of the CMV. Immunization with the disclosed CMV vectors allow selection of different CD8+ T cell responses—CD8+ T cells restricted by MHC-Ia, MHC-II, or by MHC-E.

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