EATON, Michael Anthony William,NORMAN, Timothy John,PORTER, John Robert
申请号：
ES05746563
公开号：
ES2605407T3
申请日:
2005.05.25
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound that binds to albumin selected from formulas (I), (II), (III) or (IV): ** Formula ** where: Z, Z1 and Z2 independently represent the rest of an antibody or a fragment of Fab, Fab 'or F (ab') 2 antibody or a single chain antibody； L, L1 and L2 are succinimide； Y, Y1 and Y2 independently represent a covalent bond, - (CH2) and-, or ** Formula ** B, B1 and B2 are absent or independently represent -CONH-, -NHCO-, -CO-, -OC (O ) N (R2) -, - N (R2) C (O) O- or -NHCONH-； V1 and V2 independently represent a covalent bond or - (CH2) v-； X1 and X2 independently represent CR1 or N； M1 represents a covalent bond or - (CH2) m-； W1 and W2 independently represent a covalent bond or - (CH2) w-； A1 and A2 independently represent -CONH-, -NHCO-, -CO-, -OC (O) N (R2) -, -N (R2) C (O) O- or -NHCONH-； E, E1 and E2 independently represent a covalent bond or - (CH2) e-； P, P1 and P2 are polymeric moieties comprising the repetition of the unit [OCH2CH2] n where n is between 5 and 100； T, T1 and T2 independently represent a covalent bond or linker group； F, F1 and F2 independently represent a straight chain fatty acid of between 14 and 24 carbon atoms； Q, Q1 and Q2 independently represent an acid group； R1 represents a hydrogen or C1-4 alkyl； R2 represents a hydrogen or C1-4 alkyl； e is 1, 2, 3 or 4； v is 1, 2, 3 or 4； w is 1, 2, 3 or 4； y is 1, 2, 3, 4, 5 or 6； and m is 1.2 or 3.Un compuesto que se une a albúmina seleccionado de las fórmulas (I), (II), (III) o (IV):**Fórmula** donde: Z, Z1 y Z2 representan independientemente el resto de un anticuerpo o un fragmento de anticuerpo Fab, Fab' o F(ab')2 o un anticuerpo de cadena única； L, L1 y L2 son succinimida； Y, Y1 y Y2 representan independientemente un enlace covalente, -(CH2)y-, o**Fórmula** B, B1 y B2 están ausentes o representan independientemente -CONH-, -NHCO-, -CO-, -OC(O)N(R2)-, - N(R2)C(O)O- o -NHCONH-； V1 y V2 representan independientemente un enlace covalente o -(CH2)v-； X1 y X2 representan independientemente CR1 o N； M
