MUTATIONS PONCTUELLES DANS UN ANTICORPS BISPECIFIQUE, PERMETTANT D'AUGMENTER LE TAUX DE CLAIRANCE

• 收藏
• 分享

专利权人:

IMMUNOMEDICS; INC.

发明人:

申请号：

EP03743416.4

公开号：

EP1487879B1

申请日:

2003.03.03

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

A mutant bispecific antibody that includes (a) a human hinge constant region from IgG having one or more amino acid mutations in the CH2 domain, (b) two scFvs； and (c) two Fvs has been constructed. This type of antibody displays enhanced clearance, which has been found to be particularly useful in the context of pre-targeting methods.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/