MUTATIONS PONCTUELLES DANS UN ANTICORPS BISPECIFIQUE, PERMETTANT D'AUGMENTER LE TAUX DE CLAIRANCE

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专利权人:

IMMUNOMEDICS; INC.

发明人:

QU, ZHENGXING,HANSEN, HANS,GOLDENBERG, DAVID M.

申请号：

CA2478011

公开号：

CA2478011C

申请日:

2003.03.03

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

A mutant bispecific antibody that includes (a) a human hinge constant regionfrom IgG having one or more amino acid mutations in the CH2 domain, (b) twoSCFVS； and (c) two FVS has been constructed. This type of antibody displaysenhanced clearance, which has been found to be particularly useful in thecontext of pre-targeting methods.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/