INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE);UNIVERSITE PARIS DIDEROT;UNIVERSITE PARIS DESCARTES - PARIS V;SORBONNE UNIVERSITE;SEPTODONT OU SEPTODONT SAS OU SPECIALITES SEPTODONT
The present invention relates to a regenerative material in the connective tissues (such as bone, dentin or pulp) regeneration field. More precisely, the present invention relates to a connective tissue regenerative material, preferably a bone, dentin or pulp regenerative material, comprising: - a porous polymer matrix having interconnected pores； and - non-hydrated calcium silicate particles； wherein: said polymer matrix is anhydrous； said non-hydrated calcium silicate particles have a dso granulometry, preferably ranging from 0.05 iim to less than the average diameter size of the pores of the matrix； and said non-hydrated calcium silicate particles being coated on the inside walls of the pores of the matrix. The present invention also relates to method for preparing said connective tissue regenerative material. The present invention also concerns uses of said regenerative materials, such as for example in the dental field； especially, for providing regenerative materials with improved biomechanical and osteoinductive properties (i.e. good migration, adhesion and proliferation of cells； enhanced mechanical properties； and optimal and controlled biodegradability).
